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Image Search Results
Journal: Oncotarget
Article Title: Sp1-driven up-regulation of miR-19a decreases RHOB and promotes pancreatic cancer
doi:
Figure Lengend Snippet: A. High-throughput sequencing analysis showing the altered miRNA profiles after gemcitabine treatment in ASPC-1 cells. There were totally 42 miRNAs altered by gemcitabine, including 16 down-regulated miRNAs and 26 up-regulated miRNAs. MiR-19a was among the 16 down-ragulated miRNAs. B. The miRNA profiles were altered after Rh-Endostatin treatment in ASPC-1 cells. Totally 28 miRNAs were changed by rh-endostatin, with 11 miRNAs down-regulated and 17 miRNAs up-regulated. MiR-19a was down-regulated most significantly among the altered miRNAs. C. miR-19a was further identified as the same target of both gemcitabine and rh-endostatin by qRT-PCR in ASPC-1 cells. D. it was also confirmed that rh-endostatin and gemcitabine inhibited proliferation and simultaneously down-regulated miR-19a expression levels in Panc-1 and Capan-2 cells. * p < 0.05; ** p < 0.01; *** p < 0.001.
Article Snippet: MiRNAs were extracted from pancreatic cancer tissues, and ASPC-1 cells with
Techniques: Next-Generation Sequencing, Quantitative RT-PCR, Expressing